| 
             
            Awake intubation provides many 
            advantages over the anesthetic state: 
            
            
            
             maintenance 
            of spontaneous ventilation in the event that the airway cannot be 
            secured rapidly, 
            
            
            
             increased 
            size and patency of the pharynx,   
            
            
            
             relative 
            forward placement of the base of the tongue,   
            
            
            
             posterior 
            placement of the larynx,   
            
            
            
             and 
            patency of the retropalatal space. 
               | 
          
          
            
            
              
                |   | 
               
              
                | 
                 
                Contraindications to elective 
                awake intubation include: 
                
                
                
                 patient 
                refusal,   
                
                
                
                 inability 
                to cooperate (e.g., child, profound mental retardation, dementia, 
                intoxication), 
                
                
                
                 allergy 
                to local anesthetics.  | 
               
              
                |   | 
               
              
                
                  | 
                
                   
                
                the patient must be 
                prepared 
                
                both physically and 
                psychologically  | 
                
				  | 
                
                 
                  
                Most adult patients 
                will appreciate an explanation of the need for an awake airway 
                exam and will be more cooperative once they realize the 
                importance of any uncomfortable procedures. 
				 
                   | 
               
              
                | 
                  | 
               
              
                
                
                  
                  
                    
                      
                            | 
                      
                       
                      
						supply supplemental 
                      O2   | 
                     
                   
                  
                 
                
  | 
               
              
                | 
				
                Medication used to allay anxiety | 
               
              
                | 
                   
                
                  
                    | 
					sedatives 
                     | 
                    
                    
                      | 
                    
					producing 
                    obstruction or apnea | 
                    
                    
                      | 
                    
					 
					overly sedated 
                    patient may not be able to protect the airway from 
                    regurgitated gastric contents, or cooperate with procedures.
                      | 
                   
                 
                
                    | 
               
             
            
            Small doses of benzodiazepines
			(diazepam, midazolam, lorazapam) are commonly used to alleviate 
            anxiety without producing significant respiratory depression.  
             
            
              
            
            Opioid receptor agonists (e.g., 
            fentanyl, alfentanil, remifentanil) can also be used in small, 
            titrated doses for their sedative and antitussive effects, although 
            caution must be exercised.   
            
			  
            
            Administration of antisialagogues 
            is important to the success of awake intubation techniques. 
            
            Clearing of airway secretions is 
            essential to the use of indirect optical instruments (e.g., 
            fiberoptic bronchoscope, rigid fiberoptic laryngoscope) because 
            small amounts of any liquid can obscure the objective lens. 
             
              
            
              
                | 
                 
                atropine (0.5–1 mg im or iv) 
                
                
				glycopyrrolate 
				
                
				(0.2–0.4 mg, im or 
                iv) 
                   | 
                
                  | 
                
                 
                other significant effects  | 
                
				  | 
                
                 
				by reducing 
                saliva production, these drugs increase the effectiveness of 
                topically applied local anesthetics by removing a barrier to 
                mucosal contact and reducing drug dilution.   | 
               
             
            
              
            
            Vasoconstriction of the nasal 
            passages: is needed for fiberoptic-aided intubation. 
			
              
            
			Risk for gastric regurgitation and 
            aspiration: prophylactic measures should be undertaken.  
			
			Local anesthetics 
			 
			
				
					
						| 
						 
						areas to local anesthetic therapy  | 
						
						 
                   | 
						
						 
						
          the nasal cavity / nasopharynx, the pharynx  
						
						
						base of tongue 
						
						
						the 
          larynx / trachea.   | 
					 
				 
			 
            
          
          Lidocaine, topically applied, peak onset is within 15 minutes.
           
            
          
            
              | 
               
				Lidocaine 
              preparations  | 
              
                  | 
             
            
              | 
               
				injectable / topical solution  | 
              
               
				1%, 2% 4%  | 
             
            
              | 
               
				viscous solution  | 
              
               
				1%, 2%  | 
             
            
              | 
               
				ointment  | 
              
               
				1%, 5%  | 
             
            
              | 
               
				aerosol  | 
              
               
				10%  | 
             
           
          	 
			
			  
				
					
						
						
							
								
									| 
									 
									   | 
									
									 
									
									Tips for Success  | 
								 
							 
						 
						 
						  
						
						
           
						
          
                		Patient cooperation enhanced by adequate explanation and 
						preparation 
						
          				
           
          				
          
						Control secretions (use of antisialogogue) 
						
          				
           
          				
          
						Give adequate sedation to alleviate anxiety 
						
          				
           
          				
          
						Give adequate anesthesia to ensure patient comfort 
						 
            			
              To Avoid Complications: 
						-
						Measure/calculate all drugs 
						-
						Suction excess volume of oral spray 
						-
						Cautious application of L.A. in patients with sepsis or 
						traumatized mucosa 
						-
						Monitor carefully 
						-
						Provide supplemental Oxygen 
						 
            			
              Signs & Symptoms of L.A. Toxicity: 
						-
						Seizures 
						-
						CV collapse 
						-
						Methemoglobinemia 
						 
						
						N.B. = nerve 
						block; L.A. = local anesthesia; RR = Respiratory Rate;
						 
						
						S.E. = Side 
						Effects 
						 
						
						Local 
						Anesthesia & Sedation for Airway Management in the Awake 
						Patient 
						Developed from:  
						
						Osborn I, 
						Gooden C, Follmer J, Perez A. A Taste of Anesthesia: 
						Improving Airway Topicalization (Brochure),
						Department of Anesthesiology, Mount Sinai School of 
						Medicine, Bronx, NY, 2006.  | 
					 
				 
			 
			    
			
			       
			
               |